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KMID : 0811720130170010009
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Korean Journal of Physiology & Pharmacology
2013 Volume.17 No. 1 p.9 ~ p.13
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Impact of Micellar Vehicles on in situ Intestinal Absorption Properties of Beta-Lapachone in Rats
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Jang Soung-Baek
Kim Dong-ju
Kim Seong-Yeon
Park Chang-hee
Jeong Ji-Hoon
Kuh Hyo-Jeong
Lee Jae-Hwi
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Abstract
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The aim of the present study was to examine the effect of micellar systems on the absorption of beta-lapachone (b-lap) through different intestinal segments using a single-pass rat intestinal perfusion technique. B-lap was solubilized in mixed micelles composed of phosphatidylcholine and sodium deoxycholate, and in sodium lauryl sulfate (SLS)-based conventional micelles. Both mixed micelles and SLS micelles improved the in situ permeability of b-lap in all intestinal segments tested although the mixed micellar formulation was more effective in increasing the intestinal absorption of b-lap. The permeability of b-lap was greatest in the large intestinal segments. Compared with SLS micelles, the effective permeability coefficient values measured with mixed micelles were 5- to 23-fold higher depending on the intestinal segment. Our data suggest that b-lap should be delivered to the large intestine using a mixed micellar system for improved absorption.
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KEYWORD
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Beta-lapachone, Mixed micelles, Permeability, Single-pass intestinal perfusion
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